Endocrine Abstracts

Introduction: Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited syndrome predisposing to a variety of highly vascularised tumors in different organs. Although bilateral pheochromocytoma was reported in patient with VHL disease, the coexistence of primary hyperparathyroidism is not a common condition. Herein we report a case of a primary hyperparathyroidism secondary to an ectopic secretion of intact parathyroid hormone (PTH) in a patient with VHL disease and b...

Introduction: Osteogenesis imperfecta also known as Lobstein’s disease (LD) is a rare disorder of type 1 collagen characterized by an increased susceptibility to bone fractures. Its coexistencewith primary hyperparathyroidism (PHP) was rarely described. Herein we report a new case of a primary hyperparathyroidismin a patient with a history of Lobstein’s disease.Observation: A 35-year-old woman was referred to our departmentfor hypercalcemia. He...

Background: Thyroid nodules are the most common thyroid disease. In the majority of cases, they are benign. However, 5 to 15% of nodules are cancer. The aim of our study was to determine the clinical and biological predictive factors of malignancy in thyroid nodules.Methods: We performed a retrospective descriptive study including 100 patients collected in the endocrinology department of La Rabta hospital over 18 year old period (2000–2018). All the...

Background: Ultrasound is valuable for identifying many malignant or potentially malignant thyroid nodules. The aim of this study was to evaluate the efficacy of ultrasonographic (US) features in predicting the malignancy of thyroid nodules in a group of Tunisian patients.Methods: We conducted a retrospective descriptive study including 100 patients collected in the endocrinology department of La Rabta hospital. All these patients underwent thyroidectomy...

Introduction: The goiter represents the most common of all the disorders of the thyroid gland. Many Factors may be involved in the evolution of multinodular goiter. Although thyroid stimulating hormone (TSH) was described as the most important goitrogen factor, impairment of TRH-induced TSH release was reported with nodular goiter, suggesting thyroid autonomy. Herein, we report two cases of an isolated thyrotropin deficiency in patient presented with a voluminous goiter.<p...

The risk of hypotension during Ramadan fasting in patients with adrenal insufficiency is unknown. The aim of our study was to evaluate objectively this risk.Methods: It is a prospective case-crossover study on 28 patients with known and treated AI. Patients had no hypertension and were regular fasters. All patients underwent a clinical examination and a 24-hours blood pressure monitoring during Ramadan fasting then outside fasting....

Introduction: Diabetic foot disease is a major health problem. The identification of its risk factors should guide preventive measures. The aim of this study was to determine the factors associated with diabetic foot complications.Patients and methods: It is a retrospective study including 47 patients admitted at the department of Endocrinology in La Rabta hospital for diabetic foot complications during the years 2015 and 2016. Clinical and para-clinical...

Introduction: Atrial flutter (AFL) is a rapid, regular atrial tachyarrhythmia that occurs most commonly in patients with underlying structural heart disease. Patients with tachyarrythmias as a result of thyroid storm have been typically treated with beta-blockers to decrease the heart rate and alleviate beta-receptor mediated symptoms. We report an unusual case of AFL with 1:1 atrioventricular (AV) conduction.Case report: Patient H, M 45 years old was ad...

Background: Cardiothyreosis (CT) or thyrotoxic heart is associated with higher morbidity and mortality than the other forms of hyperthyroidism. Its risk factors have been investigated in a limited number of studies. The aim of our study was to identify risk factors of CT in patients with hyperthyroidism.Methods: We identified 538 patients with a hospital discharge diagnosis of hyperthyroidism from January 2000 to December 2015. Thirty five patients were ...

Subclinical hypothyroidism (SCH) is a common disorder and indications of treatment are still being debated. The aim of our study was to describe the therapeutic and evolutionary characteristics of SCH.Methods: We undertook a longitudinal retrospective study in 110 patients with SCH biologically defined by increased serum thyroid-stimulating hormone (TSH) levels (>4 mIU/l) and normal FT4. Pregnancy, age less than 18 years, personal history of partial ...